The Browns' wideout had his greatest game of his career, catching 11 passes for 265 yards and two scores to beat the Texans 36-22 on Sunday.
Cooper's big day began on Cleveland's opening play from scrimmage when quarterback Joe Flacco connected him for 53 yards to Houston's 6.
A few plays later, Jerome Ford scored on a direct snap for a 4-yard touchdown to put the Browns up 7-0.
In the second quarter, Cooper caught a 75-yard touchdown to put Cleveland up 14-0 and they took off. The Texans scored on a 98-yard kick return. David Njoku's second-quarter 7-yard touchdown gave the Browns a 22-7 halftime advantage.
Cooper's 7-yard score capped an 18-play, 94-yard drive that lasted most of the third quarter. Cooper made a left-sideline drive-extending, toe-dragging catch on fourth-and-8 in Houston.
Cleveland substituted Flacco, Cooper, and most of the starters after Kareem Hunt's 1-yard touchdown put the Browns ahead 36-7 in the fourth quarter.
By then, Cooper had a career-high 252 yards and two scores on 10 catches.
However, the Texans scored two early touchdowns and the league's first onside kick since 2021. Flacco and Cooper had to return to seal it for the Browns. Cooper grabbed a 13-yard catch on fourth-and-7 to establish a Browns single-game record with 265 yards.